adipose tissue inflammation and ectopic lipid accumulation in heart

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Profiling the Discordant Visceral Adipose Tissue–Ectopic ...- adipose tissue inflammation and ectopic lipid accumulation in heart ,Jun 17, 2021·The accumulation of visceral adipose tissue (VAT) and ectopic liver fat (ELF) generally parallel each other, but a proportion of individuals have discordant fat deposition. The cardiometabolic profile of individuals with a discordant phenotype is unknown.Epicardial adipose tissue in obesity-related ... - HeartMay 13, 2021·Obesity is associated with the development of heart failure and is a major risk factor for heart failure with preserved ejection fraction (HFpEF). Epicardial adipose tissue (EAT) is a unique visceral fat in close proximity to the heart and is of particular interest to the study of cardiac disease. Small poorly differentiated adipocytes with altered lipid:water content are associated with a ...



Ageing, adipose tissue, fatty acids and inflammation ...

Nov 04, 2014·A common feature of ageing is the alteration in tissue distribution and composition, with a shift in fat away from lower body and subcutaneous depots to visceral and ectopic sites. Redistribution of adipose tissue towards an ectopic site can have dramatic effects on metabolic function. In skeletal muscle, increased ectopic adiposity is linked to insulin resistance through lipid mediators such ...

Adipose Tissue Inflammation and Insulin Resistance ...

Dec 12, 2012·The adipose tissue is classified in two major depots distributed throughout the body: WAT and brown adipose tissue (BAT). BAT is implicated in cold- and diet-induced thermogenesis (non-shivering thermogenesis), modulation of body temperature, energy expenditure and adiposity ( Saito et al., 2009 ; Yoneshiro et al., 2011 ).

(PDF) Inflammatory stress exacerbates ectopic lipid ...

Inflammatory stress exacerbates ectopic lipid deposition in C57BL/6J mice. Download. Related Papers. White Adipose Tissue as Endocrine Organ and Its Role in Obesity. By Nimbe Torres. Peucedanum japonicum Thunb and its Antiobesity Effects: Evidence and Related Mechanisms. By Dr. Ruwani Nugara.

Adipose Tissue Composition in Obesity and After Bariatric ...

Jun 12, 2019·The adipose tissue is a complex organ that regulates food intake and energy expenditure as well as induces low-grade inflammation. This review deals with changes in the composition and activity of the adipose organ after bariatric surgery, focusing on epicardial and ectopic fat and on relationships between white and brown adipose tissues.

COVID-19 and Obesity: Role of Ectopic Visceral and ...

Aug 16, 2021·Ectopic Fat and Adipose Tissue Dysfunction: Key Elements in the Complications of Obesity. Regional distribution of adipose tissue and the development of ectopic fat are major determinants of metabolic and cardiovascular diseases (31, 32). Dysfunction of subcutaneous adipose tissue (SAT) limits its expandability and leads to ectopic fat deposition.

Ectopic lipid storage and insulin resistance: a harmful ...

In addition to lipid accumulation in adipose tissue, obesity is associated with increased lipid storage in ectopic tissues, such as skeletal muscle and …

(PDF) Ectopic Fat Accumulation in Pancreas and Heart

Mar 23, 2021·Alterations of tissue communications include excessive lipid and later cytokine release by dysfunctional adipose tissue, intestinal dysbiosis and ectopic fat deposition in skeletal muscle.

Adapting to obesity with adipose tissue inflammation ...

Aug 11, 2017·For example, the lipid sensitive nuclear receptor PPARγ, which is active in macrophages from obese adipose tissue, might limit inflammation and maintain adipose tissue in a state of chronic low ...

Lipid accumulation in non-adipose tissue and lipotoxicity

The latter is also known as ectopic lipid accumulation and may be a … Obesity is a well-known risk factor for the development of type 2 diabetes mellitus and cardiovascular disease. Importantly, obesity is not only associated with lipid accumulation in adipose tissue, but also in non-adipose tissues.

Coronary Artery Spasm and Perivascular Adipose Tissue ...

Apr 30, 2019·Ectopic adipose tissue, defined as the deposition of fat in non-classical locations including the heart and blood vessels, may contribute to the development of cardiovascular disease by exerting a local toxic effect on adjacent vasculature. 11–13. One such ectopic adipose tissue is …

Roles of Chronic Low-Grade Inflammation in the Development ...

Jul 21, 2014·Since ectopic fat accumulation involves both adipose tissue and nonadipose tissue, the purpose of the present review was to summarize the important evidence linking inflammation with ectopic lipid deposition in both adipose tissue and nonadipose tissue, in order to improve our understanding of the mechanism of ectopic lipid deposition. 2.

Does adipose tissue inflammation drive the development of ...

Sep 01, 2020·There are two main types of AT, brown adipose tissue (BAT) and white adipose tissue (WAT) that present distinct morphology and function. WAT, the most abundant in humans, is responsible for lipid storage during excess energy periods and the ability to mobilize these reserves during periods of …

Inflamed Adipose Tissue | Arteriosclerosis, Thrombosis ...

Sep 06, 2007·Increased lipid accumulation and adipose cell enlargement is associated with increased expression of proinflammatory factors and chemokines like MCP-1 and SAA. The adipose tissue becomes inflamed and infiltrated by macrophages which further promotes the proinflammatory state and also leads to an impaired preadipocyte differentiation.

COVID-19 and Obesity: Role of Ectopic Visceral and ...

Aug 16, 2021·Ectopic Fat and Adipose Tissue Dysfunction: Key Elements in the Complications of Obesity. Regional distribution of adipose tissue and the development of ectopic fat are major determinants of metabolic and cardiovascular diseases (31, 32). Dysfunction of subcutaneous adipose tissue (SAT) limits its expandability and leads to ectopic fat deposition.

(PDF) Inflammatory stress exacerbates ectopic lipid ...

Sep 02, 2021·Effects of chronic systemic inflammation on lipid accumulation in liver, muscle and white adipose tissue from C57BL/6J mice . Mice fed with normal chow diet (NCD), NCD plus casein injection (NCD ...

Adipose Tissue Dysfunction as Determinant of Obesity ...

In metabolically unhealthy obesity, the storage capacity of SAT, the largest WAT depot, is limited, and further caloric overload leads to the fat accumulation in ectopic tissues (e.g., liver, skeletal muscle, and heart) and in the visceral adipose depots, an event commonly defined as "lipotoxicity."

Adipose-derived autotaxin regulates inflammation and ...

Feb 07, 2019·Autotaxin (ATX) is a secreted enzyme that generates the bioactive lipid lysophosphatidic acid (LPA). We generated mice with global inducible post-natal inactivation or adipose-specific loss of the Enpp2 gene encoding ATX. The animals are phenotypically unremarkable and exhibit differences in adipocyte size and adipose tissue expression of inflammatory genes after high fat feeding without gross ...

Adipose Tissue and Inflammation | IntechOpen

Feb 22, 2018·Adipose tissue is composed mainly by adipocytes and stromal-vascular fraction, which are composed by different cell types including macrophages. There are three types of adipose tissue: brown (BrAT), white (WAT), and beige (BeAT). BrAT is less abundant and is implicated in lipid oxidation and energy balance; BeAT has the pathway of adaptive thermogenesis, and WAT is endocrine in nature and ...

Adipose Tissue Inflammation and Insulin Resistance ...

Dec 12, 2012·The adipose tissue is classified in two major depots distributed throughout the body: WAT and brown adipose tissue (BAT). BAT is implicated in cold- and diet-induced thermogenesis (non-shivering thermogenesis), modulation of body temperature, energy expenditure and adiposity ( Saito et al., 2009 ; Yoneshiro et al., 2011 ).

Adipose tissue in health and disease | Open Biology

Dec 09, 2020·Indeed, ectopic lipid accumulation in cardiac and skeletal muscle can result in tissue-specific and systemic insulin resistance [113–117]. As a whole, these findings underscore the importance of proper lipid storage within the AT and away from internal organs or skeletal muscles.

Effect of 8 Weeks of Overfeeding on Ectopic Fat Deposition ...

IHL increased 46% from 1.5% to 2.2% ( P = 0.002); however, IMCL did not change. There was no association between adipocyte size and ectopic lipid accumulation. Despite similar weight gain, subjects with smaller fat cells at baseline had a greater decrease in insulin sensitivity, which was linked with upregulated skeletal muscle tissue inflammation.

(PDF) Inflammatory stress exacerbates ectopic lipid ...

Sep 02, 2021·Effects of chronic systemic inflammation on lipid accumulation in liver, muscle and white adipose tissue from C57BL/6J mice . Mice fed with normal chow diet (NCD), NCD plus casein injection (NCD ...

COVID-19 and Obesity: Role of Ectopic Visceral and ...

Aug 16, 2021·Ectopic Fat and Adipose Tissue Dysfunction: Key Elements in the Complications of Obesity. Regional distribution of adipose tissue and the development of ectopic fat are major determinants of metabolic and cardiovascular diseases (31, 32). Dysfunction of subcutaneous adipose tissue (SAT) limits its expandability and leads to ectopic fat deposition.

Identification of markers that distinguish adipose tissue ...

Aug 23, 2021·In general, repeated cross-validation for the machine learning model for ectopic adipose tissue surrounding the heart tissue was poor, nevertheless age, diastolic blood pressure, 2-acetamidophenol ...

The Role of Lipids, Lipid Metabolism and Ectopic Lipid ...

After SCI, interruption of adipose tissue innervation causes a breakdown in energy homeostasis leading to adipose tissue accumulation and ectopic lipid spillover to vital organs. If protracted, such detrimental conditions contribute to the development of insulin resistance, increased fatty acids, cardiovascular complications and metabolic syndrome.

Adipose tissue–heart crosstalk as a novel target for ...

In addition, limited storage capacity of WAT leads to the pronounced and sustained elevation of plasma lipids (hypertriglyceridemia, lipidemia) and, as a consequence, ectopic lipid accumulation in form of TAGs, phospholipids, or ceramides (Cer) in nonadipose tissue organs, such as the liver, skeletal muscle (SKM), and heart, which is known as ...