adipose tissue lipolysis and glucose screening

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Glucose and fat metabolism in adipose tissue of acetyl-CoA ...- adipose tissue lipolysis and glucose screening ,Feb 01, 2005·The mRNA level of glucose transporter 4 (GLUT4) decreased several fold in the adipose tissue of WT mice fed a HF/HC diet; however, in the adipose tissue of Acc2 -/- mutant mice, it was 7-fold higher. Moreover, lipolysis activity was higher in adipocytes of Acc2 -/- mutant mice compared with that in WT mice.Glucagon stimulates gluconeogenesis by INSP3R1-mediated ...Mar 04, 2020·Extended Data Fig. 4 Glucagon acutely stimulates gluconeogenesis by activating intrahepatic, but not white adipose tissue, lipolysis. a, Liver HSL phosphorylation ( n = 5). These blots, and blots ...



Role of cannabinoid receptor 1 in human adipose tissue for ...

Nov 17, 2016·Adipose tissue was used to test the effects of dexamethasone and the CNR1 antagonists on the adipocyte lipolysis and glucose uptake. In an acute setting, isolated fresh adipocytes were pre-incubated with the CNR1 antagonist AM281 (3 µM) for 30 min, which was then present during lipolysis.

Exercise training improves adipose tissue metabolism and ...

Adipose tissue is also an endocrine organ, which regulates glucose and lipid metabolism and secretes a large number of hormones and cytokines.1 In obesity and insulin resistance (IR), the metabolism of adipose tissue deteriorates and this is indicated by adipocyte hypertrophy and hyperplasia, macrophage infiltration, impaired insulin signaling ...

Exenatide improves both hepatic and adipose tissue insulin ...

Thus, we evaluated the acute effects of exenatide (EX) on hepatic (Hep-IR) and adipose (Adipo-IR) insulin resistance and glucose uptake. Fifteen male subjects (age = 56 ± 8 years; body mass index = 29 ± 1 kg/m 2 ; A1c = 5.7 ± 0.1%) were studied on two occasions, with a double-blind subcutaneous injection of EX (5 μg) or placebo (PLC) 30 ...

Adipose tissue mitochondrial respiration and lipolysis ...

Sep 04, 2015·A high rate of adipose tissue lipolysis, due to adipose tissue insulin resistance, will result in elevated plasma concentrations of free fatty acids (FFA) (and glycerol), which in turn limit insulin-mediated glucose uptake in muscle (10-13).

Adrenergic regulation of human adipose tissue metabolism ...

The tissue dialysate concentrations of glycerol (lipolysis index) glucose, lactate, and pyruvate were determined. The glycerol concentration in adipose tissue …

Brain Insulin Controls Adipose Tissue Lipolysis and ...

White adipose tissue (WAT) dysfunction plays a key role in the pathogenesis of type 2 diabetes (DM2). Unrestrained WAT lipolysis results in increased fatty acid release, leading to insulin resistance and lipotoxicity, while impaired de novo lipogenesis in WAT decreases the …

Abdominal subcutaneous adipose tissue insulin resistance ...

Feb 14, 2014·Adipose tissue dysfunction is considered to be a major contributory factor of NASH, ... All patients with no previous diagnosis of type 2 diabetes underwent a 75 g oral glucose tolerance test (OGTT). ... To determine the rate of lipolysis in subcutaneous adipose tissue (SAT) under basal and hyperinsulinaemic conditions area under the curve (AUC ...

Gsα deficiency in adipose tissue improves glucose ...

Jan 12, 2016·The G protein Gsα mediates the activation of lipolysis in white and brown adipose tissue (WAT and BAT) and thermogenesis in BAT by sympathetic nerves. In this study we show that Gsα deficiency in BAT and WAT leads to cold intolerance and inactive BAT in mice, as expected, but does not alter body weight or energy balance, associated with a reduction in both lipolysis and lipogenesis.

RBP4 increases lipolysis in human adipocytes and is ...

Mar 13, 2020·Insulin resistance in obesity is a complex metabolic state consisting of increased endogenous glucose production (EGP), reduced muscle glucose uptake and increased lipolysis. 1 Many studies have now demonstrated low grade inflammation, systemically and in adipose tissue in the obese state 1 but the causal relationship between inflammation and ...

Effect of training on insulin sensitivity of glucose ...

In conclusion, training enhances insulin sensitivity of glucose uptake in subcutaneous adipose tissue and in skeletal muscle. Furthermore, interstitial glycerol data suggest that training also increases insulin sensitivity of lipolysis in subcutaneous adipose tissue. Insulin per se does not influence subcutaneous adipose tissue …

Glucose enhances catecholamine-stimulated lipolysis via ...

Therefore, we determined the effect of glucose availability on catecholamine-stimulated lipolysis in 3T3-L1 adipocytes and rat adipose tissue. Methods and …

Adipose Tissue: What Is It, Location, Function, and More ...

Adipose tissue is a specialized type of connective tissue that arises from the differentiation of mesenchymal stem cells into adipocytes during fetal development. Mesenchymal stem cells are pluripotent cells that can transform into various cell types, including fat cells, bone cells, cartilage cells, and muscle cells, among others.

Partial Inhibition of Adipose Tissue Lipolysis Improves ...

Feb 19, 2013·Partial inhibition of adipose tissue lipolysis does not increase fat mass but improves glucose metabolism and insulin sensitivity through modulation of fatty acid turnover and induction of …

Adjusting Glucose-Stimulated Insulin Secretion for Adipose ...

RESEARCH DESIGN AND METHODS To characterize the adipose disposition index, we used [1-14 C] palmitate infusion to determine basal FFA turnover rate/adipose insulin resistance and an oral glucose tolerance test to characterize the first (i.e., 0–30 min) and second phase (i.e., 60–120 min) of GSIS. We validated a simplified version of the tracer infusion calculation as the product of (1 ...

Glucose and fat metabolism in adipose tissue of acetyl-CoA ...

Feb 01, 2005·The mRNA level of glucose transporter 4 (GLUT4) decreased several fold in the adipose tissue of WT mice fed a HF/HC diet; however, in the adipose tissue of Acc2 -/- mutant mice, it was 7-fold higher. Moreover, lipolysis activity was higher in adipocytes of Acc2 -/- mutant mice compared with that in WT mice.

Pathophys: Endocrine 2 Part A Flashcards | Quizlet

Promotes FFA and glucose uptake into adipose tissue and promotes fat storage (triglyceride formation from glycerol and FFA) ... Fasting plasma glucose test: direct measure of plasma glucose. Normal plasma glucose levels. 70-100mg/Gl. ... lipolysis in adipose tissue and increases plasma FFA and glycerol.

Partial Inhibition of Adipose Tissue Lipolysis Improves ...

Feb 19, 2013·Partial inhibition of adipose tissue lipolysis does not increase fat mass but improves glucose metabolism and insulin sensitivity through modulation of fatty acid turnover and induction of …

Adipose Tissue Lipoprotein Lipase and Hormone-Sensitive ...

Oct 01, 1997·Two of the IRS patients had a diabetic glucose tolerance test (despite normal fasting blood glucose levels). A separate analysis of LPL and HSL activity, excluding these two patients, gave the same results as those for the whole group. ... Marked regional variations in adipose tissue lipolysis have been reported by several authors. 1.

Whole-body and adipose tissue glucose metabolism in ...

Mar 01, 2001·However, the effect of early fasting (≤24 h) on whole-body and adipose tissue glucose metabolism in persons with abdominal obesity is unknown. The purpose of this study was to evaluate the effect of early fasting on whole-body and adipose tissue glucose metabolism in both lean women and women with abdominal obesity.

Brain Insulin Controls Adipose Tissue Lipolysis and ...

White adipose tissue (WAT) dysfunction plays a key role in the pathogenesis of type 2 diabetes (DM2). Unrestrained WAT lipolysis results in increased fatty acid release, leading to insulin resistance and lipotoxicity, while impaired de novo lipogenesis in WAT decreases the …

Exercise training improves adipose tissue metabolism and ...

Adipose tissue is also an endocrine organ, which regulates glucose and lipid metabolism and secretes a large number of hormones and cytokines.1 In obesity and insulin resistance (IR), the metabolism of adipose tissue deteriorates and this is indicated by adipocyte hypertrophy and hyperplasia, macrophage infiltration, impaired insulin signaling ...

Insulin induced hypoglycaemia: comparison of glucose and ...

AIMS—To investigate the dynamics between plasma and dialysate glucose during hypoglycaemia in children. STUDY DESIGN—Six children in prepuberty or early puberty were investigated by multiple blood sampling and microdialysis of subcutaneous adipose tissue during a standard arginine-insulin tolerance test.Glucose and glycerol, as an index of lipolysis, were measured in samples from both ...

Glucose and Lipid Fluxes in the Adipose Tissue after Meal ...

Mar 01, 2006·Hyperthyroidism increased fasting rates of lipolysis in the adipose tissue (P = 0.02 vs. EU). This was completely suppressed within the first 60 min after the beginning of the meal. After 240 min, adipose tissue lipolysis in HR was gradually increased to levels observed in the fasting state (P = 0.001 for differences from EU at 300–360 min ...

Direct effects of glucagon on glucose uptake and lipolysis ...

Mar 01, 2020·Adipose tissue samples obtained from cohort 1, 2 and 3 were used to measure the adipose tissue gene expression of GCGR (n = 40, 68, and 27 respectively). All experiments exploring the effects of glucagon treatment in adipocyte glucose uptake (n = 22), lipolysis (n = 8) and effects on the activation of key insulin signalling proteins (n = 8) were performed in samples from cohort 2.

Tofogliflozin Improves Insulin Resistance in Skeletal ...

Glucose tolerance and insulin sensitivity were ameliorated. The serum levels of nonesterified fatty acid and ketone bodies were increased and the respiratory quotient was decreased in the tofogliflozin-treated mice, suggesting the acceleration of lipolysis in the white adipose tissue and hepatic β-oxidation.

Infrequent Feeding of Restricted Amounts of Food Induces ...

Nov 05, 2018·The alternating FR1 group showed impaired glucose tolerance compared with the alternating FR2 group. These results indicate that infrequent feeding of restricted amounts of food could induce stress hormones, lipolysis, adipose tissue immune cell infiltration and inflammation, which in turn may promote glucose metabolism disorder.