adipose tissue-resident immune cells key players in immunometabolism

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Chronic adipose tissue inflammation: all immune cells on ...- adipose tissue-resident immune cells key players in immunometabolism ,Inflammation is indispensable for host homeostasis against invading pathogens and efficient wound healing upon tissue malfunction and has to be tightly controlled by various mechanisms to limit excess responses harmful to host tissues. A myriad of disease conditions ranging from type 2 diabetes (T2D) to neurodegenerative and cardiovascular disorders are now shown to progress due to persistent ...The FAT expandability (FATe) Project: Biomarkers to ...Apr 22, 2015·Schipper HS, Prakken B, Kalkhoven E, Boes M. Adipose tissue-resident immune cells: key players in immunometabolism. Trends Endocrinol Metab. 2012;23:407–15. Article CAS PubMed Google Scholar 39. Micheel CM, Nass SJ, Omenn GS. Evolution of Translational Omics: Lessons Learned and the Path Forward.



Frontiers | T Cells in Adipose Tissue: Critical Players in ...

Immunometabolism has emerged as a major mechanism central to adaptive and innate immune regulation. From early observations that inflammatory cytokines were induced …

B Lymphocytes and Adipose Tissue Inflammation ...

Mar 05, 2020·Adipose tissue-resident immune cells: key players in immunometabolism. Trends Endocrinol Metab. 2012; 23:407–415. doi: 10.1016/j.tem.2012.05.011 Crossref Medline Google Scholar; 7. Mraz M, Haluzik M. The role of adipose tissue immune cells in …

Obese adipose tissue modulates proinflammatory responses ...

Jun 30, 2021·Brown and white adipose tissues: intrinsic differences in gene expression and response to cold exposure in mice. Am J Physiol Endocrinol Metab 306: E945–E964, 2014. doi: 10.1152/ajpendo.00473.2013. Link | ISI | Google Scholar; 14. Schipper HS, Prakken B, Kalkhoven E, Boes M. Adipose tissue-resident immune cells: key players in immunometabolism.

B Lymphocytes and Adipose Tissue Inflammation ...

Adipose tissue-resident immune cells: key players in immunometabolism. Trends Endocrinol Metab. 2012; 23:407–415. doi: 10.1016/j.tem.2012.05.011 Crossref Medline Google Scholar; 7. Mraz M, Haluzik M. The role of adipose tissue immune cells in obesity and …

JCI - Macrophages, fat, and the emergence of immunometabolism

Dec 02, 2013·Although the initial immunometabolism studies focused on adipose tissue, it is now evident that metabolic activation of the immune system is not limited to fat of obese individuals. Obesity has now been shown to change immune cell populations in the liver, bone marrow, key regulator areas of the hypothalamus, and the circulation.

Cardiac adipose tissue volume and IL-6 level at admission ...

Aug 12, 2021·Schipper HS, Prakken B, Kalkhoven E, Boes M. Adipose tissue-resident immune cells: key players in immunometabolism. Trends Endocrinol Metab. …

B Lymphocytes and Adipose Tissue Inflammation ...

Mar 05, 2020·Adipose tissue-resident immune cells: key players in immunometabolism. Trends Endocrinol Metab. 2012; 23:407–415. doi: 10.1016/j.tem.2012.05.011 Crossref Medline Google Scholar; 7. Mraz M, Haluzik M. The role of adipose tissue immune cells in …

Editor’s Pick: Immunometabolism in Rheumatic Disease: The ...

Jul 29, 2019·Introduction. The field of immunometabolism is a rapidly expanding area of research that centres around understanding the interrelationship between immunological and metabolic processes. 1 Activation of the immune system is a dynamic process that requires significant immune metabolic reprogramming to induce and maintain proliferation of immune cells, as well as activation and …

Chronic adipose tissue inflammation: all immune cells on ...

In adipose tissue, immune cells are identified in the stromal vascular fraction (SVF) after enzymatic digestion, processing, and centrifugation of adipose tissue. These cells play important roles such as maintaining the well-being of adipocytes, removal of apoptotic cells, and sustaining tissue homeostasis in nonobese mice and humans [12].

The NLRP3 inflammasome regulates adipose tissue metabolism ...

Adipose tissue regulates metabolic homeostasis by participating in endocrine and immune responses in addition to storing and releasing lipids from adipocytes. Obesity skews adipose tissue adipokine responses and degrades the coordination of adipocyte lipogenesis and lipolysis. These defects in adipose tissue metabolism can promote ectopic lipid deposition and inflammation in insulin-sensitive ...

Adipose Tissue Dendritic Cells: Critical Regulators of ...

Chronic inflammation of the adipose tissue (AT) is a critical component of obesity-induced insulin resistance and type 2 diabetes. Adipose tissue immune cells, including AT macrophages (ATMs), AT dendritic cells (ATDCs), and T cells, are dynamically regulated by obesity and participate in obesity ...

Metabolic adaptations of tissue-resident immune cells ...

Jun 18, 2019·Adipose tissue stands out as one of the best-studied tissues in terms of the function of tissue-resident immune cells. Macrophages, along with other types of innate and adaptive immune cells …

Regulation of immunometabolism in adipose tissue ...

Dec 05, 2017·Adipose tissue has emerged as a major player in driving obesity-related inflammatory response. In obesity, chronic infiltration of macrophages in adipose tissue mediates local and systemic inflammation and acts as a key contributor to insulin resistance. In the past few years, adipose tissue plasticity and remodeling capacity has been studied extensively to develop therapeutic targets to ...

TL1A regulates adipose-resident innate lymphoid immune ...

Jan 30, 2020·Schipper HS, Prakken B, Kalkhoven E, Boes M. Adipose tissue-resident immune cells: key players in immunometabolism. Trends Endocrinol Metab. …

T Cells in Adipose Tissue: Critical Players in ...

Oct 30, 2018·In addition, several other immune cell populations or subsets mainly associated with type 2 immune response, such as type 2 innate lymphoid cells (ILC2) …

EoTHINophils: Eosinophils as key players in adipose tissue ...

Mar 13, 2020·In recent years, the importance of immune cells in the regulation of adipose tissue homeostasis has been a focal point of research efforts. There is an abundance of anti-inflammatory innate immune cells in lean white adipose tissue, including macrophages, eosinophils and group 2 innate lymphoid cells, which promote energy homeostasis and ...

Mycobacterium tuberculosis infection modulates adipose ...

Oct 17, 2017·Schipper HS, Prakken B, Kalkhoven E, Boes M. Adipose tissue-resident immune cells: key players in immunometabolism. Trends in endocrinology and metabolism: TEM. 2012;23(8):407–15. Epub 2012/07/17. pmid:22795937. View Article PubMed/NCBI Google Scholar 44.

Immuno-metabolism and adipose tissue: The key role of ...

Jun 21, 2015·Adipose tissue-resident immune cells: key players in immunometabolism. Schipper HS , Prakken B , Kalkhoven E , Boes M Trends Endocrinol Metab, (8):407-415 2012

Chronic adipose tissue inflammation: all immune cells on ...

Inflammation is indispensable for host homeostasis against invading pathogens and efficient wound healing upon tissue malfunction and has to be tightly controlled by various mechanisms to limit excess responses harmful to host tissues. A myriad of disease conditions ranging from type 2 diabetes (T2D) to neurodegenerative and cardiovascular disorders are now shown to progress due to persistent ...

Natural Killer Cells and Their Role in Immunometabolism ...

Natural Killer cells - an overview Natural Killer (NK) cells were first described in the mid-1970’s as a population of innate lymphocytes that were able to mediate cytotoxicity against tumour cells without prior exposure to a target (Herberman et al., 1975, I and II). NK cells are found in primary and secondary immune compartments, some mucosal tissues and are continually circulating ...

Ginger (Zingiber officinale) Attenuates Obesity and ...

Jan 13, 2021·Obesity is characterized by excessive fat accumulation in adipose tissue, which is an active endocrine organ regulating energy metabolism. Ginger (Zingiber …

Single cell analysis reveals immune cell–adipocyte ...

Oct 23, 2019·The data enhance our understanding of the role of adipose tissue immune cells in regulating adipose function and systemic metabolic homeostasis. This work will have impact in the field of immunometabolism and will provide a framework for further research on the signaling pathways that control adipocyte thermogenesis.

Immuno-metabolism and adipose tissue: The key role of ...

May 01, 2016·The field of immunometabolism has come a long way in the past decade, leading to the emergence of a new role for white adipose tissue (WAT) that is now recognized to stand at the junction of immune and metabolic regulations. Interestingly, a crucial role of the abundant and heterogeneous immune population present in WAT has been proposed in the ...

systemic immunometabolism challenges and opportunities ...

Systemic Immunometabolism: Challenges and Opportunities ... -resident memory T cells acetyl-CoA. tumor cell FFAs short-chain fatty acids Ganeshan hepatic portal vein heart non-immune cells adipose tissue lumen lipid macrophages TNFa Stoeckius intraepithelial lymphocytes cell-cell acute myeloid leukemia patients intestine immune cells antigen ...

[PDF] The role of adipose tissue immune cells in obesity ...

Adipose tissue (AT) lies at the crossroad of nutrition, metabolism, and immunity; AT inflammation was proposed as a central mechanism connecting obesity with its metabolic and vascular complications. Resident immune cells constitute the second largest AT cellular component after adipocytes and as such play important roles in the maintenance of AT homeostasis.

SVF (Adipose Tissue Derived MSC) Based Therapy for CKD ...

May 07, 2019·Banas A, Teratani T, Yamamoto Y, Tokuhara M, Takeshita F, Osaki M, Kawamata M, Kato T, Okochi H, Ochiya T. IFATS collection: in vivo therapeutic potential of human adipose tissue mesenchymal stem cells after transplantation into mice with liver injury. Stem Cells. 2008 Oct;26(10):2705-12. doi: 10.1634/stemcells.2008-0034. Epub 2008 Jun 5.